Effect of Natural Extract Leaves Waru (Hibiscus tiliaceus L) on Structure Liver of White Male Rats (Rattus novergicus Berkenhout 1769)

Resti Chatijah, Titrawani ., Ennie Chahyadi

Abstract


The waru plant (Hibiscus tiliaceus L) is one of the potentially medicinal plants and belongs to the Family Malvaceae. Waru Plants are trusted and used by the community to clean up the blood postpartum, fever, vomiting blood, cough and shortness of breath. Study of side effects especially the use of natural extract of medicinal plants has not been done, especially on the leaves of waru and one of the organ that are often damaged because the metabolism of chemical compounds is the liver. The purpose of this research is to study the change of histology structure of liver tissue caused by the giving of natural extract of waru leaf. This study used 9 rats divided into 3 groups namely: P0 (control), P15 (given the natural extract waru dose 100 mg/kgBB for 15 days), and P30 (given the natural extract waru dose 100 mg/kgBB for 30 days). Preparation of histological preparations using parafin method, Hemayoxylin-Eosin staining. At P0, the average damage was 2.87%, while at P15 5.58%, and there was an increase at P30 equal to 11.32%. The hearts of white rats undergo histopathological changes in the form of hydropic degeneration, fat degeneration, necrosis, vascular congestion, and sinosoid congestion. In this case the giving of natural extract of leaves waru with dose 100 mg/kgBB allegedly affect the structure of liver cells. But the change are still within normal limits due to the degree of minor damage of 25%.


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